Tetrazin 25 | Online Purchase | Free Home Delivery | Bangladesh
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Tetrazin 25mg Tablet

Generic: Tetrabenazine

Type: Tablet

Pack Size: 10 Pcs

Tetrazin 25mg Tablet is used in the treatment of chorea (abnormal, jerky, or involuntary movements) associated with Huntington’s disease, an inherited condition in which the nerve cells in the brain become damaged. 


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Discount Price: ৳ 332.5
MRP: ৳ 350 5% Off

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✅ Description:

Tetrazin 25mg Tablet contains Tetrabenazine, which belongs to the group of medicines called Vesicular monoamine transporter 2 inhibitors. It is primarily used to treat hyperkinetic motor disorders associated with Huntington's chorea, an inherited neurodegenerative disease characterized by jerky, irregular, and uncontrollable movements.

It's important to note that Tetrazin 25mg Tablet is contraindicated in patients allergic to Tetrabenazine. Additionally, it should not be used in individuals with Parkinson-like symptoms, depression, active suicidal thoughts, pheochromocytoma (tumor of the adrenal gland), or kidney disorders.

Before starting treatment with Tetrazin 25mg Tablet, inform your doctor if you have any intolerance to certain sugars (such as lactose), heart problems like long QT syndrome heart rhythm disorders, or liver problems ranging from mild to severe hepatic disorders.

Caution should be exercised when using Tetrazin 25mg Tablet during pregnancy or in women planning for pregnancy, only if deemed necessary by the physician. However, it is not recommended for use in breastfeeding women.

This medication is not suitable for use in children and adolescents below 18 years of age. For elderly patients aged 65 years and above, Tetrazin 25mg Tablet should be used with caution after consulting a doctor.

Safety Advices


Alcohol
UNSAFE

Avoid alcohol consumption while taking Tetrazin 25mg Tablet, as it may increase drowsiness.


Pregnancy
UNSAFE

Use Tetrazin 25mg Tablet during pregnancy only if necessary, after consulting your doctor.


Breastfeeding
UNSAFE

Avoid using Tetrazin 25mg Tablet while breastfeeding. Consult your doctor for advice.


Driving
CAUTION

Do not drive or operate machinery if you feel drowsy after taking Tetrazin 25mg Tablet.


Kidney
CONSULT YOUR DOCTOR

Consult your doctor before using Tetrazin 25mg Tablet if you have kidney disorders.


Liver
CONSULT YOUR DOCTOR

Tetrazin 25mg Tablet with caution if you have liver problems. Consult your doctor before use.

Similar Products

✔️ Uses of Tetrazin 25mg Tablet

Huntington's disease

✔️ How does Tetrazin 25mg Tablet work?

Tetrazin 25mg Tablet works by reducing the level of certain chemicals that cause abnormal movements.

✔️ Side Effects of Tetrazin 25mg Tablet

Depression and suicidality are two major adverse responses. Akathisia, restlessness, and agitation are all symptoms of Akathisia. Dysphagia, Parkinsonism Somnolence, and sedation

✔️ Over dosage of Tetrazin 25mg Tablet

If an overdose occurs, seek medical attention immediately. Symptoms may include muscle spasms, uncontrolled eye movements, nausea, vomiting, dizziness, confusion, hallucinations, and tremors.

✔️ Quick Suggestions:
  • You have been prescribed Tetrazin 25 to help control movement disorders such as revocHuntington’s disease.
  • Be cautious while driving or doing anything that requires concentration as Tetrazin 25 can cause dizziness and sleepiness.
  • Inform your doctor if you experience symptoms such as high fever, sweating, muscle stiffness, and faster breathing. These may be due to a rare side effect known as the neuroleptic malignant syndrome.
  • Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
  • Do not stop taking Tetrazin 25 without talking to your doctor first as it may cause worsening of symptoms.
✔️ Indication of Tetrazin 25mg Tablet

Movement disorders, Moderate to severe tardive dyskinesia

✔️ Pharmacology

Tetrabenazine acts as a reversible inhibitor of human vesicular monoamine transporter type 2 (VMAT2). It primarily functions in the basal ganglia to deplete reserves of monoamine neurotransmitters such as serotonin, norepinephrine, and dopamine. By lowering synaptic vesicle uptake, tetrabenazine effectively reduces the transmission of dopamine, which is essential for fine motor movement. This mechanism makes it effective for treating hyperkinetic movement disorders associated with conditions like Huntington's disease.

It's worth noting that tetrabenazine exhibits a low affinity for the dopamine D2 receptor in vitro, indicating that its therapeutic effects are primarily mediated through VMAT2 inhibition rather than direct interaction with dopamine receptors.

✔️ Dosage & Administration of Tetrazin 25mg Tablet

For the treatment of chorea associated with Huntington's disease in adults, the recommended oral dosage of tetrabenazine should be individualized and titrated slowly over several weeks to identify a dose that effectively reduces chorea and is well tolerated. The total daily dose can be up to 50 mg/day.

Here are the dosing recommendations:

  1. Initial Dose: Start with 12.5 mg taken orally once daily.
  2. Week 2: After one week, increase the dose to 12.5 mg taken orally twice daily (every 12 hours).
  3. Maintenance Dosing: Slowly titrate the dose by weekly intervals of 12.5 mg/day to identify the lowest effective dose that reduces chorea and is well tolerated.
  4. If the daily dose is between 37.5 to 50 mg/day: Administer the dose in divided doses every 8 hours.
  5. Elderly Patients: Start with an initial dose of 12.5 mg daily and gradually increase as tolerated.
  6. Total Daily Dose >50 mg/day: If a dose higher than 50 mg/day is required, patients should be tested and genotyped to determine if they are poor or extensive metabolizers of CYP2D6. The dose should be individualized accordingly, not exceeding 100 mg/day or 37.5 mg per dose.
  7. Moderate to Severe Tardive Dyskinesia: Initially start with 12.5 mg daily and increase gradually based on response.
  8. Hepatic Impairment: Tetrabenazine is contraindicated in patients with hepatic impairment, as the dose cannot be adjusted to ensure safe use.
✔️ Interaction

Inform your doctor about all medications you are taking, including:

  • Reserpine
  • MAO inhibitors
  • Levodopa
  • Opioids
  • Antihypertensive drugs
  • Beta-blockers
  • Antipsychotic medications
  • CYP2D6 inhibitors
  • Medications prolonging the QTc interval
  • Certain antibiotics
  • Medications for heart rhythm conditions
✔️ Contraindications

Do not take Tetrazin 25mg Tablet if you are allergic to Tetrabenazine or any other ingredients in the medication.

✔️ Pregnancy & Lactation

The pregnancy classification for tetrabenazine is Category C, indicating that there are no sufficient and well-controlled trials in pregnant women. Therefore, tetrabenazine should only be used during pregnancy if the potential benefits to the mother outweigh the potential risks to the fetus.

Regarding breastfeeding, tetrabenazine or its metabolites are not known to be excreted in human milk by nursing mothers. However, it's essential to consider that many medications can pass into breast milk and potentially cause adverse reactions in nursing infants. Therefore, a decision should be made whether to discontinue breastfeeding or discontinue tetrabenazine, taking into account the importance of the medication to the mother's health and the potential risks to the infant. This decision should be made in consultation with a healthcare professional.

✔️ Precautions & Warnings
  • Use Tetrazin 25mg Tablet cautiously if you have heart problems such as long QT syndrome or heart rhythm issues. Consult your doctor before use.
  • Avoid using Tetrazin 25mg Tablet if you have Parkinson-like symptoms, untreated or difficult-to-treat depression, active suicidal thoughts, or pheochromocytoma. Inform your doctor if you have prolactin-dependent tumors or if you are intolerant to certain sugars.
  • Not recommended for use in children and adolescents under 18 years old. Consult your doctor before use.
  • Use with caution in elderly patients aged 65 years or older. Consult your doctor before use.
✔️ Storage Conditions

Protect from light and moisture by storing in a cool, dry place below 30°C. Keep out of children's reach.

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